Leaving the airport, follow the signs for Pittsburgh. The road you’re on eventually becomes I-279. Follow the signs for I-279 / Pittsburgh.
Just past the Greentree exit, I-279 begins a long descent toward the Fort Pitt tunnels. Get into the right lane at this point. (Watch out for long backups on this hill during morning rush hour.)
At the bottom of the hill, just before the tunnels, take exit 5C for Route 51 North / Route 19 North / West End.
Then, follow signs for Station Square / South 837. Route 51 will merge onto West End Circle. Stay in the right lane and follow it right onto West Carson Street. You will see the river on your left as you head toward Pittsburgh.
On West Carson Street, stay in the left lane. Once you pass Station Square and the Smithfield Street bridge, West Carson Street becomes East Carson Street.